On the Efficacy of 'Butyl Acridine' in the Treatment of Malaria

General.?Recently it has been shown by Siddons and Bose (1944) that the compound (2-chloro-7 methoxy 5S-diethyl-amino-butyl) amino-acridine, hereafter called the butyl acridine, was highly effective in controlling the infection of Plasmodium knowlesi in rhesus monkeys even in small doses. The same compound has previously been shown by one of us (Basu and Bose, 1941) to exert a considerably higher lethal effect on cultures of Paramecium -caudatum than the corresponding amylacridine derivative commonly known as atebrin. Further as the anti-malarial action of compounds follows closely their effect on paramoecia (Kindler, 1938), it was considered to be of interest to study the effect of this drug even in smaller doses on human malaria cases. Experimental.?A total of 27 adult cases of human malaria was studied in our out-door clinical department. The patients were all employees of the firm, and hence control during treatment was rigid, and each case was easily followed after treatment as long as it was necessary. Out of the 27 cases, 22 were of benign tertian infection and the rest of malignant tertian. Quartan cases were not encountered. Assessment.?Immediately after admission, thick and thin blood films were examined for